How to tweak my own transit settings on the front-end?

With the help of Muuntaja, I’ve written my own Transit encoders for my back-end that can handle Instants and soon UUIDs. What I’m not sure about is how to make the parallel decoders on the front-end, where I’m using re-frame-http-fx for my ajax requests. I lifted the following from @yogthos Luminus, but in that code-base as-transit isn’t actually called anywhere, and I’m not sure where I would use it. How should I setup my transit reading on the front-end so that data I receive over the wire correctly interprets my custom special types (Instant, UUID) into the matching Clojurescript things?

(ns myproject.ajax
  (:require [ajax.core :as ajax]
	    [luminus-transit.time :as time]
	    [cognitect.transit :as transit]))

(defn as-transit [opts]
  (merge {:raw             false
	  :format          :transit
	  :response-format :transit
	  :reader          (transit/reader :json time/time-deserialization-handlers)
	  :writer          (transit/writer :json time/time-serialization-handlers)}
	 opts))